Absolutely. Even though PayPal allows anyone to make a payment using their credit/bank card, alot of customers don't know this and they move on to the next host that can take their card directly. Also, some do not wish to use PayPal, at all.

I did noticed an increase in signups after I attached a note during the checkout process, stating that anyone with a credit/bank card can make a payment, even if they do not have a PayPal account. This has worked pretty good with the clients that have never heard about PayPal.

I do agree that at some point, any succesful online business will have to eventually accept credit cards directly through their website and be PCI compliant.