Yes, almost all of our customers pay using PayPal also, and a few here and there that use AlertPay. However, I want to reach to those buyers that do not want to use PayPal or create an account with AlertPay, and just want to use their credit cards without any fuzz. That's what attracted me to 2CO.
I'm also looking at CDG Commerce, but wanted something that would be close enough to a merchant account, without having to go through all the PCI Compliance steps, yet. The weekly payments can be a drag, but at least it goes straight into your business bank account, so waiting a week or two is really not that bad.