Fantastico is great asset to have. It makes installing many scripts very easy if you don't know how to do it on your own. Many host provide it to help their clients. Personally I have used it a few times, but not always.
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Fantastico scripts are quite widely used, the common being wordpress, joomla, etc, the only point to be noted while using the same would be that you should constantly keep upgrading the software as and when the new version is available, and keep a regular check on the fantastico forums to be notified of any known backdoors, and patches available for the softwares.
I have used it a few times before it's comes in pretty handy. But like you I mostly use wordpress. The list bobchrist put up was pretty handy and I didn't know fantastico had ALL those features. It is fanatastic!
I always make sure to get fantastico because of Wordpress but I didn't know how much more there was involved. I truly need to get out of my rut and play around with more of this stuff - even if it's a just for fun site so I can learn more of the scripts.
I will mess around with it sometimes but mostly for personal use I am only using the wordpress, or I will add/remove to test things out just to see how they work. I am not too found of coppermine for photos, but gallery is tolerable.
Please your clients & thank them from time to time.......they are just like groupies that keep the band going strong.