Paypal by far, it is very popular as the other guy said. I also have been using it for a while, so I personally like it over MoneyBookers and so do others. Most business's also support it.
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Is there any reason why you wouldn't use Moneybookers?
We use it, however if I am not mistake that Moneybookers have only average popularity in UK.... in other countries this payment system isn't popular at all.
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I'm sure Google Checkout will give Paypal a run for their money when it becomes more globally used. Paypal still has a high level of fraud and it's something the need and have yet improved on.
My vote has been registered and I am on the majority side. More than 80 percent has said that paypal is the best.
I dont offer any other payment options other than paypal, as all my clients are available in local. I never say paypal is the best in security. It has a very high level of threats, but it is still used because of its global recognition.