There's a number of things on the blind side of things such as text to speach recognizers. There's a number of programs on the market that will read the text of a page to someone, but very few people build with this in mind.
For the deaf, I don't think websites matter (if it's informational) in that there really shouldn't be any music or noises on a site anyway. The only time you should have noise is if it's required as part of a marketing plan to make a sale. Beyond that, music and sounds do not belong on standard websites.
I tend to agree with Conor for the majority of sites, but the popularity of programs like SitePal are proof that video and audio can enhance your marketing efforts.
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