Depends on your target audience.
Not everyone has flash plugins installed (I don't on ANY of my computers)
Not everyone has a cable connection (modem users will hate you)
Not everyone likes music and flashing graphics - I hate it personally
If you want to reach the largest audience, go with what has been a proven marketing/media device for centuries - black text on a white (light) background - newspapers, magazines are this way for a reason. Being forced to site through an animation is like watching commercials on TV. I just want the info, and then get out. I definitely wouldn't use it in a business site (unless you're targeting kids).